The CCN family of proteins: structure–function relationships
نویسندگان
چکیده
منابع مشابه
The CCN family proteins in carcinogenesis.
The CCN (Cyr61 (cysteine-rich protein 61), CTGF (connective tissue growth factor), Nov (nephroblastoma overexpressed)) family consists of six members that belong to matricellular proteins of extracellular matrix (ECM). Like other matricellular proteins, CCN members do not primarily have a structural role; however, they modulate cell-ECM interactions. In general, CCN proteins are formed by four ...
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phatic communion is a cultural concept which differs across cultures. according to hofstede (2001), the u.s. tends to have individualistic culture; however, asian countries tend to have collectivistic cultures. these cultures view phatic communion differently. in individualistic cultures like u.s., phatic communion reflects speakers’ socio-cultural relationships in conversations. to see whether...
15 صفحه اولCCN Family: Matricellular Proteins in Cartilage and Bone Development
The extracellular matrix is the intricate scaffolding which surrounds and supports cells and helps to organize them into tissues and organs. The CCN family of matricellular proteins helps to regulate and modulate production, degradation, and remodeling of the extracellular matrix. In this chapter, we review the extracellular matrix of cartilage and bone, including an overview of chondrogenesis ...
متن کاملMatricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system
Matricellular proteins are secreted proteins that exist at the border of cells and the extracellular matrix (ECM). However, instead of playing a role in structural integrity of the ECM, these proteins, that act as modulators of various surface receptors, have a regulatory function and instruct a multitude of cellular responses. Among matricellular proteins are members of the Cyr61/CTGF/NOV (CCN...
متن کاملThe First International Workshop on CCN Proteins
The novH gene is the human homologue of the chicken nov proto-oncogene, which is overexpressed in avian nephroblastomas. The NOVH protein is a member of the CCN family of proteins likely to play a role in cell growth regulation. We have investigated novH expression at RNA and protein levels in prostate epithelial cell lines derived from normal tissues (SV4O large T antigen immortalised PNT1A an...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2008
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2008.07.006